While you will be able to remotely access your virtual machine through Spice without making any change to the virtual machine configuration, you can get better integration if you tweak it specially for Spice.
If your virtual machine has a QXL video device and you install the corrresponding guest driver, your guest will support higher resolutions, multiple monitors, resizing to arbitrary resolutions, …
Installing the Spice vdagent in your guest will let you copy and paste between your guest and client OSes, to drag and drop files between the 2 OSes, … In order for the agent to work, your virtual machine must have a virtio serial device (and the corresponding guest drivers) as well as a Spice spicevmc channel.
The recommended way of getting all the needed drivers installed is to use the all-in-one Spice guest tools installer which can be found on spice-space.org.
If you want to manually install them, the QXL driver can be downloaded from this location , agent builds can be found here. You also need the vioserial driver which is distributed with the other virtio-win drivers.